Accepted_test

Phylogenetic analysis of the tumor-specifically expressed pseudogene ENSG00000186076

by Potter Ivan | Andrei Makashov | State budgetary educational institution Secondary school No. 225 | Peter the Great St. Petersburg Polytechnic University

Abstract ID: 680

Event: BGRS-abstracts

Sections: [Sym 4] Section “Human origin and evolution”

In this paper, we performed a phylogenetic analysis of the non-coding gene ENSG00000186076. This gene is located at chromosome 12 and has been identified as a processed pseudogene of PGAM1 gene. According to Bibert et al, 2021 the ENSG00000186076 gene expression is significantly reduced in a group of patients with severe COVID-19, indicating the level of expression of this gene is associated with the severity of disease. The homologs were searched in 15 genomes of species of the human lineage.

We found 15 processed pseudogenes in the human genome, which demonstrated high levels of similarity with the ENSG00000186076 sequence. The homologues of this gene were found in Primates only. Moreover, the most extensive pseudogenization of PGAM1 gene has been observed in Catarhhini.
We found that ENSG00000186076 expression is increased in esophageal carcinoma, glioblastoma, kidney renal clear cell carcinoma, lung squamous cell carcinoma, ovarian serous cystadenocarcinoma and stomach adenocarcinoma. The highest expression levels were found in glioblastoma.