Accepted_test

IL-6 knockout mice in STZ-induced diabetes model

Authors:
Svetlana K. Purtova, Engelhardt Institute of Molecular Biology of Russian Academy of Sciences, Moscow, Russia
Ekaterina O. Gubernatorova, Engelhardt Institute of Molecular Biology of Russian Academy of Sciences, Moscow, Russia
Ekaterina A. Gorshkova, Engelhardt Institute of Molecular Biology of Russian Academy of Sciences, Moscow, Russia

Abstract ID: 720

Event: BGRS-abstracts

Sections: [Sym 7] Section “Animal genetic models of human pathologies on vertebrates and invertebrates”

Interleukin-6 (IL-6) is a multifunctional cytokine that is involved in proinflammatory and homeostatic processes in the body. However, excessive and prolonged IL-6 production can lead to the development of health issues. Chronic exposure to IL-6 in peripheral tissues and hepatocytes can cause inflammation, leading to insulin resistance and diabetes. The exact role of IL-6 in diabetes and its complications is not completely clear. Therefore, here we report about to evaluate the impact of IL-6 deficiency in mice on the severity of diabetes and diabetic nephropathy.
Eventually, a whole-body IL-6 knockout mouse model was effective in reproducing STZ-induced diabetes. It has been shown that IL-6 is deficient, mice develop more severe symptoms of diabetes, as well as more pronounced immune cell infiltration of the kidneys related. It indicates a protective role for this cytokine.