Accepted_test

IL-6 knockout mice in STZ-induced diabetes model

by Svetlana K. Purtova | Ekaterina O. Gubernatorova | Ekaterina A. Gorshkova | Engelhardt Institute of Molecular Biology of Russian Academy of Sciences, Moscow, Russia | Engelhardt Institute of Molecular Biology of Russian Academy of Sciences, Moscow, Russia | Engelhardt Institute of Molecular Biology of Russian Academy of Sciences, Moscow, Russia

Abstract ID: 720

Event: BGRS-abstracts

Sections: [Sym 7] Section “Animal genetic models of human pathologies on vertebrates and invertebrates”

Interleukin-6 (IL-6) is a multifunctional cytokine that is involved in proinflammatory and homeostatic processes in the body. However, excessive and prolonged IL-6 production can lead to the development of health issues. Chronic exposure to IL-6 in peripheral tissues and hepatocytes can cause inflammation, leading to insulin resistance and diabetes. The exact role of IL-6 in diabetes and its complications is not completely clear. Therefore, here we report about to evaluate the impact of IL-6 deficiency in mice on the severity of diabetes and diabetic nephropathy.
Eventually, a whole-body IL-6 knockout mouse model was effective in reproducing STZ-induced diabetes. It has been shown that IL-6 is deficient, mice develop more severe symptoms of diabetes, as well as more pronounced immune cell infiltration of the kidneys related. It indicates a protective role for this cytokine.