Accepted_test

Development of computer tools to search for microRNA targets

by Radochin P.A. | Voronina A.A. | Orel D.Y. | Smirnova O.A. | Golubchikov D.O. | Mak D.V. | Voronova S.S. | Volkov I.A. | Savina E.A. | Orlov Y.L. | Sechenov First Moscow State Medical University of the Russian Ministry of Health (Sechenov University), Moscow, Russia | St.Petersburg Polytechnical University, St.-Petersburg, Russia | St.Petersburg Polytechnical University, St.-Petersburg, Russia | Sechenov First Moscow State Medical University of the Russian Ministry of Health (Sechenov University), Moscow, Russia | Sechenov First Moscow State Medical University of the Russian Ministry of Health (Sechenov University), Moscow, Russia | Sechenov First Moscow State Medical University of the Russian Ministry of Health (Sechenov University), Moscow, Russia | Sechenov First Moscow State Medical University of the Russian Ministry of Health (Sechenov University), Moscow, Russia | Sechenov First Moscow State Medical University of the Russian Ministry of Health (Sechenov University), Moscow, Russia | Engelhardt Institute of Molecular Biology RAS Novosibirsk, Russia | Sechenov First Moscow State Medical University of the Russian Ministry of Health (Sechenov University), Moscow, Russia

Abstract ID: 768

Event: BGRS-abstracts

Sections: [Sym 1] Section “Regulatory genomics”

The study of the molecular mechanisms of complex diseases is an important task of biomedicine, requiring data integration and the development of new bioinformatic tools. microRNAs are a class of non-coding RNA molecules that regulate the translation and degradation of their MRNA targets through interaction, which makes the study of their functions in diseases necessary to elucidate their pathogenetic mechanisms. miRNAs play an important role in regulating gene expression. New literature data are emerging on the role of microRNAs in tumor progression, the development of mental disorders, liver diseases, and chronic diseases. A scientific project for the study of microRNA target genes within the Digital Department of Sechenov University in the 2023-2024 academic year is presented [3]. Mastering the use of existing online programs for computer search of microRNA target genes in the genome, and developing proprietary programs for predicting microRNA binding sites in genes. The problem being solved within the framework of the presented project is training on the problems of using bioinformatics tools to analyze the structure of RNA and microRNA, the mechanisms of binding RNA to human gene transcripts. The available software tools for searching for microRNA target genes have been collected, and a data processing pipeline has been prepared.