Accepted_test

A new approach for ultrafast in situ fabrication of stabilised colloidal highly efficient magnetoelectric (ME) core–shell nanoparticles (NPs) was developed on the basis of biocompatible magnetic MnFe₂O₄ (MFO) and ferroelectric Ba_0.85Ca_0.15Zr_0.1Ti_0.9O₃ (BCZT) using a microwave-assisted hydrothermal method. Opposite effects on growth of cancer and normal cells were revealed in vitro by electrostimulation via ME MFO@BCZT NPs using a low-intensity AC magnetic field (7 mT, 10 Hz). An improved cellular uptake and efficient wireless stimulation of mouse hippocampal neurons were also demonstrated ex vivo. Moreover, enhanced trans-synaptic axonal transport of cargoes to the brain and specifically modulated odour processing were detected in vivo by means of ME MFO@BCZT NPs as a non-invasive platform for wireless electrical stimulation. Thus, in this study, a novel advanced strategy is established based on non-invasive intracellular ME nanosized electrodes for neurological theranostics and targeted drug delivery to the central nervous system.