by Dudko N. | Andreeva T. | Manakhov A. | Shepeleva D. | Shihevich S. | Kharlamova A | Rogaev E. | Center of Genetics and Life Sciences, Federal Territory Sirius, Sirius University of Science and Technology, Sochi, Russia | Center of Genetics and Life Sciences, Federal Territory Sirius, Sirius University of Science and Technology, Sochi, Russia; Laboratory of Evolutionary Genomics, Department of Genomics and Human Genetics, Vavilov Institute of General Genetics, RAS, Moscow, Russia | Center of Genetics and Life Sciences, Federal Territory Sirius, Sirius University of Science and Technology, Sochi, Russia; Laboratory of Evolutionary Genomics, Department of Genomics and Human Genetics, Vavilov Institute of General Genetics, RAS, Moscow, Russia; Center for Genetics and Genetic Technologies, Moscow State University, Moscow, Russia | Institute of Cytology and Genetics, SB RAS, Novosibirsk, Russia | Institute of Cytology and Genetics, SB RAS, Novosibirsk, Russia | Institute of Cytology and Genetics, SB RAS, Novosibirsk, Russia | Center of Genetics and Life Sciences, Federal Territory Sirius, Sirius University of Science and Technology, Sochi, Russia; Center for Genetics and Genetic Technologies, Moscow State University, Moscow, Russia; Department of Psychiatry, Umass Chan Medical School, Shrewsbury, MA, USA
A complex phenotype, behavior depends on a variety of signaling pathways including oxytocinergic, serotoninergic, and hypothalamic-pituitary ones. The Vulpes vulpes model was used to determine the genetic components that influence aggressive behavior toward humans. SNPs and SVs that distinguished across groups were found in the genomes of aggressive, tame, and non-selected animals. There were found to be several genes with retrocopies lacking in one group and present in another. For the first time, Vulpes vulpes frontal brain epigenetic profiles were acquired, examined, and contrasted between the groups under study. Significant differences were observed in the levels of enrichment for histone marks h3k4me3 and h3k27ac of genes participating in the signaling pathways of the estrogen receptor, "ERK (MAPK/ERK)", "neuroactive interaction of ligand and receptor", "axonal pathfinding", and "serotonergic" synapse" between aggressive and tame animals. The study was supported by the Ministry of Science and Higher Education of the Russian Federation (Agreement 075-10-2021-093 (project GEN-RND-2017).
