Accepted_test

We managed to demonstrate immune privileges of mesenchymal stem cells. In the following review, I marked a deep mutual interference between immune and stem cells, and basing on the complexity of stem cells regulation suggested the term “stem system”. Yet, the question about mechanisms underlying the phenomenon stayed unconsidered. I further continued to study literature for described molecular mechanisms responsible for immune suppression.

Various immune suppressing mechanisms contributing to the complex network and to the formation of immune privileges are described in literature. The amount of available information makes aggregation a complex task requiring new automated approaches. The problem expands beyond a quantity of information to its complexity.

This topic presents the problem from the side of classic biology. The subject is too big to be fitted to only one discipline. A systemic approach from programming, big data analysis and mathematic are required as well. The actual aim of the topic is to initiate a discussion and a possible cooperation for a further study.