Methylation and expression profiles in Apoe vicinity point to specific neighboring interaction of Apoe and TOMM40 genes: implication for The Alzheimer disease.

Vladimir Babenko^1
1Institute of Cytology and Genetics SB_RAS, bob@bionet.nsc.ru

We assessed the dynamics of 8 genes including TOMM40, Apoe and other adjacent ones for overall chromatin marks landscape, including methylation profiles across ENCODE brain cell lines, and histone and ctcf marks. We revealed the region manifests Hi-C topology dynamics in a cell-specific manner. Additionally, based on methylation and histone marks profiles we underscore competitive manner of genes expression implying disrupted locus wide genes expression balance in Alzheimer patients due to Apoe extended locus methylation profile alteration.