Way to longevity: role of antioxidant defense gene polymorphisms in successful adaptation

Poster (download) Vera Erdman1, Timur Nasibullin2, Ilsia Tuktarova3, Ksenia Danilko4, Alisa Matua5, Tatiana Viktorova6, Olga Mustafina7 1IBG UFRC RAS, danivera@mail.ru 2IBG UFRC RAS, nasibullintr@yandex.ru 3IBG UFRC RAS, iltuk@mail.ru 4BSMU, kse-danilko@yandex.ru 5SRI EPT ASA, azmatua@mail.ru 6BSMU, t_vict@mail.ru 7IBG UFRC RAS, anmareg@mail.ru We carried out the analysis of associations between polymorphic loci of antioxidant defense genes with ethnicity and longevity. We found the interethnic differences in the distribution of allele frequencies of SOD1, SOD2, CAT, NQO1 genes. For reaching longevity SOD1, SOD2, NQO1, GPX1 genes were significant among Russians, SOD2 genes – among Tatars, MSRA  genes – among Bashkirs.

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Study of personal qualities and EEG activity in a stop signal paradigm in residents of northern regions

Poster (download) Tatiana Asakhova1, Alexander Saprigyn2, Sergey Tamozhnikov3, Alexandra Karpova4, Natalya Borisova5, Elena Afanaseva6, Alexander Savostyanov71NSU, Novosibirsk, Russia, t.astakhova@g.nsu.ru2State Scientific-Research Institute of Physiology & Basic Medicine, Novosibirsk, Russia, saprigyn@mail.ru3State Scientific-Research Institute of Physiology & Basic Medicine, Novosibirsk, Russia, stam@physiol.ru4North-Eastern Federal University, Yakutsk, Russia, karpova74@list.ru5North-Eastern Federal University, Yakutsk, Russia, borinat@yandex.ru6North-Eastern Federal University, Yakutsk, Russia, eb.afanaseva@mail.ru7State Scientific-Research Institute of Physiology & Basic Medicine, Novosibirsk, Russia ICG SB RAS, Novosibirsk, Russia NSU, Novosibirsk, Russia, alexander.savostyanov@gmail.com It is known that the adaptation to new conditions depends on personality traits. The results obtained showed that the lower level of anxiety and neurotism, the better behavioural control and adaptation. Also, the adaptation level is the lowest right after the move to another place, and it grows by the time along with the growth of behavioral control.

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Genomic Signals of Adaptation in the Northern Ural and Western Siberian Populations

Poster (download) Gennady Khvorykh1, Giang Vu2, Andrey Khrunin31Institute of Molecular Genetics of the Russian Academy of Sciences, Moscow, Russia, khvorykh@img.ras.ru2Moscow Polytechnic University, Moscow, Russia, vuminhgiang135@gmail.com3Institute of Molecular Genetics of the Russian Academy of Sciences, Moscow, Russia, khrunin@img.ras.ru The evolution of humans was influenced by environmental conditions, particularly when they left Africa. Exploration of the genetic variations in the populations leaving in extreme climates will lead to better understanding of molecular-genetics mechanisms of adaptation. In the current study we investigated the genome-wide data of Khahty, Mansi, and Nenets people for signatures of selection using the population branch statistic test and revealed strong signals located in a cluster of alcohol dehydrogenase 1 genes. We hypothesize that it can be due to the limited diversity of food intake the indigenous people of the Northern Ural and Siberian experience.

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