The algorithm for finding potentially oscillating behavior in enzymatic systems

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Tatiana N. Lakhova¹, Fedor V. Kazantsev², Yuriy G. Matushkin³, Sergey A. Lashin⁴
¹Bioinformatics and Information Technologies in Genetics, Kurchatov genome center ICG SB RAS, tlakhova@bionet.nsc.ru
²Sector for computer analysis and simulations of biological systems, Kurchatov genomics center ICG SB RAS, kazfdr@bionet.nsc.ru
³Laboratory of molecular genetic systems ICG SB RAS, mat@bionet.nsc.ru
⁴Sector of Bioinformatics and Information Technologies in Genetics, Kurchatov genomics center ICG SB RAS, Novosibirsk State University, lashin@bionet.nsc.ru

Enzymatic reactions regulate Р° lot of processes in a cell. Chemical compounds such as various inhibitors, activators, cofactors, allosteric regulators, etc. may influence reaction rate. We are interested in the oscillatory processes that play role in the functioning of biological systems. It is known that oscillatory behavior frequently emerges via influence of the positive and/or negative feedback loops. Development and analysis of mathematical and computer models may be the tools to explore such behavior. Therefore, the aim of our research is to develop the technology that can help find potentially oscillating microbial enzymatic subsystems and to explore their behavior.

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Alexandra Klimenko

3 years ago

How do you take into account reaction modifiers (panel IV) in your reconstructed math models?

Tatiana Lakhova

Thank you for a good question. We take into account reaction modifiers in according to Mass action law and enzyme kinetics, using Hill’s functions, Michaelis and Menten equation and so on. In this specific case all modifiers in the model was fixed with an initial concentration.