Poster (download) Svetlana Viktorovna Michurina1, Svechnikova Natalia Nikolaevna2, Andrey Yurievich Letyagin3, Irina Yurievna Ishchenko4, Sergey Alekseevich Arkhipov5, Solovyova Anastasia Olegovna6, Konenkov Vladimir Iosifovich71Group of experimental pharmacology SRICEL – a branch of ICG SB RAS Novosibirsk, Russia, s.michurina@ngs.ru2Laboratory of clinical immunogenetics SRICEL – a branch of ICG SB RAS Novosibirsk, Russia, n.svechnikova@ngs.ru3Laboratory of pharmaceutical technologies SRICEL – a branch of ICG SB RAS Novosibirsk, Russia, letyagin-andrey@yandex.ru4Group of experimental pharmacology SRICEL – a branch of ICG SB RAS Novosibirsk, Russia, irenisch@mail.ru5Group of experimental pharmacology SRICEL – a branch of ICG SB RAS Novosibirsk, Russia, arhipowsergei@yandex.ru6Laboratory of pharmacological active compounds SRICEL – a branch of ICG SB RAS Novosibirsk, Russia, solovevaao@gmail.com7Laboratory of clinical immunogenetics SRICEL – a branch of ICG SB RAS Novosibirsk, Russia, vikonenkov@gmail.com Congestion in the blood and lymphatic vessels is detected in the papillary and reticular layers in the skin dermis of patients with pigment urticarial. This promotes the development of microcirculatory disorders and the formation of perivascular infiltrates. LYVE-1 positive staining was detected not only in the endothelium of the lymphatic vessels (both in the skin papillary layer and in the deeper dermis layers), but also in the prickle cells of the stratum spinosum and (less pronounced) in the cells of the stratum basal in the epidermis. Our 3D modeling of the LYVE-1 marker expression in skin epidermis suggests that mainly the prickle cells of the epithelium stratum spinosum and to a lesser extent the cells of the epithelium basal layer in patients with cutaneous mastocytosis participate in the lymphatic transport of hyaluronan and the spaces between these cells can be considered as prelimfatiks of the skin epidermis.

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