Poster (download) Nikita Alkin1, Yakov Dunaevsky2, Mikhail Belozersky3, Galina Beliakova4, Valeriia Tereshchenkova5, Elena Elpidina61MSU Faculty of Biology, Moscow, Russia, nikita9801@mail.ru2MSU Belozersky IPCB, Moscow, Russia, dun@belozersky.msu.ru3MSU Belozersky IPCB, Moscow, Russia, mbeloz@belozersky.msu.ru4MSU Faculty of Biology, Moscow, Russia, adm-odo@yandex.ru5MSU Faculty of Chemistry, Moscow, Russia, v.tereshchenkova@gmail.com6MSU Belozersky IPCB, Moscow, Russia, elp2@yandex.ru Subtilisin-like peptidases (SLPs) play an important role in digestion and host colonization of pathogenic fungi. Analysis of 42 fungal genomes from all major taxa of Ascomycota and Basidiomycota was performed. Homologs of enzymes from all 4 major families of SLPs were found is the examined genomes. The most abundant types of the SLP homologs found were those of kexin and proteinase K families; pyrolysin homologs were detected in the half of the observed species; in addition, several homologs of OSP family proteins were found. Alignments of homologous amino acid sequences with type SLPs indicated presence of intact conserved domains and active sites. Number of SLP homologs differ distinctly between species from different environmental niches with the highest variety of SLPs found in pathogenic and parasitic fungi.

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