Inflammation is associated with desynchronosis in the immune system (experimental study).

Poster (download) Abdalova A.M.1, Shurlygina A.V.2, Dergacheva T.I.3, Klimontov V.V.4, Letyagin A.Yu.51Research Institute of Clinical and Experimental Lymphology – Branch of the Institute of Cytology and Genetics SB RAS, arzuabd@mail.ru2Research Institute of Clinical and Experimental Lymphology – Branch of the Institute of Cytology and Genetics SB RAS, anna_v_s@mail.ru3Research Institute of Clinical and Experimental Lymphology – Branch of the Institute of Cytology and Genetics SB RAS, dr-tanja@yandex.ru4Research Institute of Clinical and Experimental Lymphology – Branch of the Institute of Cytology and Genetics SB RAS, klimontov@mail.ru5Research Institute of Clinical and Experimental Lymphology – Branch of the Institute of Cytology and Genetics SB RAS, letyagin-andrey@yandex.ru The circadian temporary organization of the dynamic processes occurring at the level of the cellular compartment of the immune system ensures their clear time sequence, the optimal ratio of cellular elements in organs and tissues at any given time/ Any pathological process leads to biorhythmological disorders of varying severity, which begin at the very early stages of the disease, when clinical signs are not yet manifested. However, in the literature there is very little information about the daily biorhythms of the immune system in violation of its functions, in particular, in the chronic inflammatory process. We found that with inflammation in the thymus, spleen and lymph nodes, the nature of the diurnal fluctuations in the content of large, medium and small lymphocytes, monocytes / macrophages, CD8 +, CD25 + cells changes. Thus, with the development of inflammation in the uterine mucosa in rats, desynchronosis in the immune system is observed. This allows us to talk about the need to take into account circadian rhythms in the diagnosis and treatment of inflammatory diseases.  

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THE EFFECT OF THE MELATONIN-CONTAINING PREPARATION ON THE HISTOLOGICAL STRUCTURE OF THE ORGANS OF THE IMMUNE SYSTEM OF MICE UNDER ROUND-THE-CLOCK ILLUMINATION

Poster (download) Shurlygina A.V1, Serykh A.E.2, Rachkovskaya L.N.3, Michurina S.V.4, Rachkovsky E.E.5, Letyagin A.Yu.61Research Institute of Clinical and Experimental Lymphology – Branch of the Institute of Cytology and Genetics SB RAS., anna_v_s@mail.ru2Research Institute of Clinical and Experimental Lymphology – Branch of the Institute of Cytology and Genetics SB RAS, .Novosibirsk State University, rasiel1996@yandex.ru3Research Institute of Clinical and Experimental Lymphology – Branch of the Institute of Cytology and Genetics SB RAS, noolit@niikel.ru4Research Institute of Clinical and Experimental Lymphology – Branch of the Institute of Cytology and Genetics SB RAS, s.michurina@ngs.ru5Research Institute of Clinical and Experimental Lymphology – Branch of the Institute of Cytology and Genetics SB RAS, noolit@niikel.ru6Research Institute of Clinical and Experimental Lymphology – Branch of the Institute of Cytology and Genetics SB RAS, letyagin-andrey@yandex.ru In modern time person’s everyday life, the light regime is often disrupted. It entails a decrease in the synthesis of melatonin. Melatonin influences the differentiation of lymphocytes, the activity of inflammation, and the strength of the immune response. Study\’s purpose is the identification of histological features of the thymus and spleen of mice by means of oral administration of a new melatonin-containing preparation (Complex M) in conditions of light regime\’s disruption under round-the-clock illumination. In the experiment, we used mice with SPF status (inbred strain C57Bl / 6J), males, aged 10-12 weeks. It was shown that the introduction of Complex M reduces the relative size of spleen\’s white pulp, increases the size of the reactive centres, the marginal zone of the spleen follicles and venous vessels of the organ. In addition, the introduction of Complex M increases the cortical-brain index of the thymus, which may indicate This may be a sign of activation of immune functions, increased venous blood flow and stimulation of the central differentiation of T-lymphocytes.  

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