• June 29, 2020
  • N/A

Disruptive natural selection by male reproductive potential prevents underexpression of the genes encoding proteins on the human Y chromosome as a self-domestication syndrome

Poster (download) Mikhail Ponomarenko1, Irina Chadaeva2, Dmitry Oshchepkov3, Dmitry Rasskazov4, Alexander Osadchuk5, Ludmila Osadchuk61Systems Biology Department Institute of Cytology and Genetics, ICG SB RAS Novosibirsk, Russia, pon@bionen.nsc.ru2Systems Biology Department Institute of Cytology and Genetics, ICG SB RAS Novosibirsk, Russia, ichadaeva@bionet.nsc.ru3Systems Biology Department Institute of Cytology and Genetics, ICG SB RAS Novosibirsk, Russia, diman@bionet.nsc.ru4Systems Biology Department Institute of Cytology and Genetics, ICG SB RAS Novosibirsk, Russia, rassk@bionen.nsc.ru5Animal Genetics Department Institute of Cytology and Genetics, ICG SB RAS Novosibirsk, Russia, osadchuk@bionet.nsc.ru6Animal Genetics Department Institute of Cytology and Genetics, ICG SB RAS Novosibirsk, Russia, losadch@bionet.nsc.ru We performed an in silico genome-wide analysis of all SNPs located within 70 bp proximal promoters in front of the all experimentally knowns starts of protein-coding transcripts from human Y chromosome within the framework of the current release #151 of the dbSNP database and GRCh38/hg38 assembly of the human reference genome, which are publicly available using the UCSC Genome Browser. As a result, we first found disruptive natural selection by male reproductive potential preventing underexpression of the Y-linked proteins under this study as if self-domestication would have happened during the human origing and evolution that could cause male fertility disorders as self-domestication syndrome.

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Patterns of maternal and paternal inheritance in Russian populations

Poster (download) Anton Logachev1, Daisuke Hirata2, Gaik Tamazian31St. Petersburg State University, a.logachev@spbu.ru2St. Petersburg State University, d.khirata@spbu.ru3St. Petersburg State University, g.tamazian@spbu.ru Genome Russia (GR) study is a national collaboration to expand our understanding of demographic history of peoples of Russia, to get deep insight into population genetics and to create a detailed genetic map of a country. Here we report analyses of matrilineal and patrilineal inheritance derived from whole genome sequencing data collected in the framework of the project. We examined sequences of 171 Y-chromosomes and 322 mtDNA ascertained from 14 ethnicities. We determined haplogroups for both Y-chromosomes and mtDNA sequences and estimated their distribution across the country. We performed phylogenetic and population genetic analyses for mtDNA and Y-chromosomes separately and then compared the results to reveal genetic history of indigenous groups living in Russia.

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