Associations of polymorphic variants of the genes of neurotrophic factors BDNF, NGF, NRG1 with remission in patients with depressive disorders

Natalia Vyalova¹, German Simutkin², Nikolay Bokhan³, Svetlana Ivanova^4
1Mental Health Research Institute of the Federal State Budget Scientific Institution \”Tomsk National Research Medical Center of the Russian Academy of Sciences\”, Natarakitina@yandex.ru
²Mental Health Research Institute of the Federal State Budget Scientific Institution \”Tomsk National Research Medical Center of the Russian Academy of Sciences\”, ggsimutkin@gmail.com
³Mental Health Research Institute of the Federal State Budget Scientific Institution \”Tomsk National Research Medical Center of the Russian Academy of Sciences\”, bna909@gmail.com
⁴Mental Health Research Institute of the Federal State Budget Scientific Institution \”Tomsk National Research Medical Center of the Russian Academy of Sciences\”, ivanovaniipz@gmail.com

The investigation the relationship between BDNF, NGF and NRG1 genotypes with remission in patients with MDD was made in a group of 208 patients. The study showed that rs3924999 of the NRG1 gene was associated with clinical remission, rated on the HDRS-17 scale on day 28 of antidepressant therapy.