Poster (download)
14
Kazakov Oleg1, Poveshchenko Alexander2, Orlov Nikolai3, Kabakov Alexey4, Lykov Alexander5, Strunkin Dmitry6, Konenkov Vladimir7
1Research Institute of Clinical and Experimental Lymphology – Branch of the Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, kazakoff_oleg@mail.ru
2Research Institute of Clinical and Experimental Lymphology – Branch of the Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, poveshchenkoa200@mail.ru
3Research Institute of Clinical and Experimental Lymphology – Branch of the Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, nbo@ngs.ru
4Research Institute of Clinical and Experimental Lymphology – Branch of the Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, kabakov_av85@mail.ru
5Research Institute of Clinical and Experimental Lymphology – Branch of the Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, aplykov2@mail.ru
6Research Institute of Clinical and Experimental Lymphology – Branch of the Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Strunkind@mail.ru
7Research Institute of Clinical and Experimental Lymphology – Branch of the Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, vikonenkov@gmail.com
The correlation analysis of the morphometry of mesenteric lymph nodes and cytokines of the chest duct lymph in chemically induced breast cancer was carried out. The study showed that in breast cancer, the activity of the local immune response in the lymph nodes is aimed at antitumor protection. In breast cancer, the area of the paracortical zone remains at the level of the intact group, the area of lymphoid nodules with germinative centers and the area of medullary substance are increased, the number of macrophages in the thymus-dependent zone and zone responsible for humoral immunity is increased. In breast cancer positive correlation were revealed: in the germinative centers and medullary substance – mitotically dividing cells with cytokine IL-5, medium lymphocytes with chemokine MIP-1О±, in the germinative centers – immunoblasts with cytokine GRO/KC, in the paracortical zone – chemokine MCP-1 with macrophages, reticular cells with IL-6 and M-CSF, in medullary substance – small lymphocytes and mature cells plasma cells (the number of which is decrease) with chemokine Gro/KC, that can be caused by their migration from lymph nodes.В