FMO superfamily protein phylogeny and the origin of YUCCA family.

Igor Turnaev¹, Valentin Suslov², Konstantin Gunbin³, Dmitriy Afonnikov⁴
¹Institute of Cytology and Genetics, ICG SB RAS Novosibirsk, Russia, turn@bionet.nsc.ru
²Institute of Cytology and Genetics, ICG SB RAS Novosibirsk, Russia, valya@bionen.nsc.ru
³Institute of Cytology and Genetics, ICG SB RAS Novosibirsk, Russia, genkvg@bionen.nsc.ru
⁴Institute of Cytology and Genetics, ICG SB RAS Novosibirsk, Russia, ada@bionen.nsc.ru

We performed a comparative analysis of phylogeny, conservative sites, protein domains, and the presence in taxa of FMOs and BVMOs proteins. Earlier in the FMOs, the following protein groups were distinguished: type I FMO, type II FMO, YUCCAs. According to the results of our analysis, we propose that the type II FMO group is, in turn, divided into two groups: FMO IIA type and type IIB FMO. Type IIB FMO proteins represent a new special group in a number of parameters (site consensus, composition of protein domains, presence in taxa and, apparently, functions) significantly different from all other FMOs proteins and type IIA FMO proteins, in particular. While type IIA FMO proteins exhibit properties typical of the FMO subclass. The type IIB FMO protein group is likely to represent a new family of proteins. These proteins are of interest for biocatalysis.

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Konstantin Gunbin

3 years ago

Igor, why the phylogenetic position of typeIIb FMO is so unstable in the case of protein analysis by MrBayes? Is it the consequence of convergent amino acid changes or protein evolution model misspecification?