Functional Roles of the E3 Ubiquitin Ligase HYD in Drosophila Tissues

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Iuliia Galimova¹, Natalia Vladimirovna Dorogova², Svetlana Fedorova^3
1IMCB SB RAS, Novosibirsk, Russia, galimova@mcb.nsc.ru
²ICG SB RAS, Novosibirsk, Russia, dorogova@bionet.nsc.ru
³ICG SB RAS, Novosibirsk, Russia, fsveta@bionet.nsc.ru

Drosophila tumor suppressor HYD is required for the regulation of cell proliferation, growth and differentiation. HYD is involved in cell processes at different levels: it can regulate gene expression by binding to its promoters, it binds to some RNA for gene silencing and it participates in protein degradation due to its ubiquitin-ligase activity. Analysis of Drosophila hyd mutants revealed that HYD functions depend on tissue and stage of development: misexpression in larval somatic tissues causes over-proliferation, defects of meiosis and spermatid differentiation in spermatogenesis, and massive cell death with occasional germline overproliferation during oogenesis.