Arina Degtyareva1, Elena Leberfarb2, Ilya Brusentsov3, Tatiana Kuzina4, Tatiana Merkulova5
1ICG SB RAS, degtyareva_rso@mail.ru
2ICG SB RAS, lieberfarb@bionet.nsc.ru
3ICG SB RAS, brusentsovi@gmail.com
4NSU, t.kuzina@g.nsu.ru
5ICG SB RAS, merkulova@bionet.nsc.ru
In a previous study using a new bioinformatic approach based on Chip-Seq data with antibodies to various transcription factors , histone markers , and ChiA-PET and RNA-seq data, 32 potentially regulatory single -nucleotide polymorphisms (SNPs) were associated with colorectal cancer . In this study, a functional analysis of 6 of these polymorphisms was performed using EMSA and the luciferase reporter system. These nucleotide substitutions have been shown to alter the binding of oligonucleotides to nuclear extract proteins and alter the expression of the reporter gene.
jazz music
Jazz Escape
peaceful music
tender soft sleep jazz piano music
bossa nova jazz
harp instrumental music
jazz cafe
smooth jazz
snowfall jazz
cozy fireplace
relaxing jazz background music