Genetic Polymorphism Associated with Infectious Pulmonary Diseases in Siberian Populations and Among Patients with Community Acquired Pneumonia

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Svetlama V. Mikhailova^1
1ICG SB RAS, mikhail@bionet.nsc.ru

Innate immune system is the first to respond to pathogen invasion; it activates adaptive immunity and regulates the intensity of inflammation. Two single nucleotide polymorphisms of the innate immunity genes: rs5743708 of the TLR2 and rs8177374 of the TIRAP were shown to be associated with pneumonia and tuberculosis, but the data are contradictory in different ethnic groups. We assessed the prevalence of these variants in Caucasoid and Asian population samples, and among patients with community acquired pneumonia (CAP). Carriage of the rs5743708 A allele was found to be predisposed to severe CAP (OR=2.77, p=0.021), GG/CT genotype for rs5743708 / rs8177374 is proved to be protective against it (OR=0.478, p=0.022) in Caucasoid patients. Both Caucasoid and Asian studied populations were turn to be different from European and neighboring Asian populations on the genotypes prevalence. Differentiation of CAP by the causative pathogen could help to eliminate the currently observed contradictions between different research groups.