Pavel Madonov1, Roman Knyazev2, Konstantin Ershov3
1Department of experimental pharamacology Research Institute of Clinical and Experimental Lymphology – Branch of the Institute of Cytology and Genetics Siberian Branch of the Russian Academy of Sciences Novosibirsk, Russian Federation Department of pharmacology, clinical pharmacology and evidence-based medicine Novosibirsk State Medical University Novosibirsk, Russian Federation, Pmadonov@yandex.ru
2Research Institute of Biochemistry -Branch of the Federal Research Center of Fundamental and Translational Medicine Department of pharmacology, clinical pharmacology and evidence based medicine Novosibirsk State Medical University Novosibirsk, Russian Federation, Knjazev_roman@mail.ru
3Department of pharmacology, clinical pharmacology and evidence-based medicine Novosibirsk State Medical University,Novosibirsk, Russian Federation, Ershov_k@bk.ru
Immobilized subtilisins are bacterial proteinases with high thrombolytic activity that can improve peripheral circulation by dissolving a blood clot and reducing the manifestations of endothelial dysfunction. This article presents materials on the effect of immobilized subtilisins on heart performance in an experiment. The action of these proteinases was studied on a model of an isolated rat heart according to Langendorff. For registration, heart rate (HR) and pressure developed by the left ventricle (HDL) were selected. When immobilized subtilisins were added, an increase in left ventricular contraction force and a decrease in heart rate were shown. The results show that immobilized subtilisins have positive inotropic and negative chronotropic effects.