Laser 3D-modeling in research of molecular features of skin lymphatic vessels in the patients with urticaria pigmentosa

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Svetlana Viktorovna Michurina1, Svechnikova Natalia Nikolaevna2, Andrey Yurievich Letyagin3, Irina Yurievna Ishchenko4, Sergey Alekseevich Arkhipov5, Solovyova Anastasia Olegovna6, Konenkov Vladimir Iosifovich7
1Group of experimental pharmacology SRICEL – a branch of ICG SB RAS Novosibirsk, Russia, s.michurina@ngs.ru
2Laboratory of clinical immunogenetics SRICEL – a branch of ICG SB RAS Novosibirsk, Russia, n.svechnikova@ngs.ru
3Laboratory of pharmaceutical technologies SRICEL – a branch of ICG SB RAS Novosibirsk, Russia, letyagin-andrey@yandex.ru
4Group of experimental pharmacology SRICEL – a branch of ICG SB RAS Novosibirsk, Russia, irenisch@mail.ru
5Group of experimental pharmacology SRICEL – a branch of ICG SB RAS Novosibirsk, Russia, arhipowsergei@yandex.ru
6Laboratory of pharmacological active compounds SRICEL – a branch of ICG SB RAS Novosibirsk, Russia, solovevaao@gmail.com
7Laboratory of clinical immunogenetics SRICEL – a branch of ICG SB RAS Novosibirsk, Russia, vikonenkov@gmail.com

Congestion in the blood and lymphatic vessels is detected in the papillary and reticular layers in the skin dermis of patients with pigment urticarial. This promotes the development of microcirculatory disorders and the formation of perivascular infiltrates. LYVE-1 positive staining was detected not only in the endothelium of the lymphatic vessels (both in the skin papillary layer and in the deeper dermis layers), but also in the prickle cells of the stratum spinosum and (less pronounced) in the cells of the stratum basal in the epidermis. Our 3D modeling of the LYVE-1 marker expression in skin epidermis suggests that mainly the prickle cells of the epithelium stratum spinosum and to a lesser extent the cells of the epithelium basal layer in patients with cutaneous mastocytosis participate in the lymphatic transport of hyaluronan and the spaces between these cells can be considered as prelimfatiks of the skin epidermis.

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Vadim Nimaev
Vadim Nimaev
3 years ago

Your data is very interesting due to application of modern morphological equipment. We are waiting for next incestigations. Thank you.

IRINA
IRINA
3 years ago

Спасибо за комментарий

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