MIRNA EXPRESSION PROFILE IN ABNORMALLY INVASIVE PLACENTA: ACCRETA, INCRETA AND PERCRETA CASES

Poster (download)

403

Angelika Timofeeva¹, Oksana Vasilchenko², Mariya Pirogova³, Ivan Fedorov⁴, Vitaliy Chagovets⁵, Larisa Ezhova⁶, Roman Shmakov⁷, Gennadiy Sukhikh^8
1FSBI В«National Medical Research Center For Obstetrics, Gynecology And Perinatology Named After Academician V.I.KulakovВ» Ministry of Healthcare of the Russian Federation, Moscow, Russia, avtimofeeva28@gmail.com
²FSBI В«National Medical Research Center For Obstetrics, Gynecology And Perinatology Named After Academician V.I.KulakovВ» Ministry of Healthcare of the Russian Federation, Moscow, Russia, vasilchenko-on@mail.ru
³FSBI В«National Medical Research Center For Obstetrics, Gynecology And Perinatology Named After Academician V.I.KulakovВ» Ministry of Healthcare of the Russian Federation, Moscow, Russia, pirogovamariya@gmail.com
⁴FSBI В«National Medical Research Center For Obstetrics, Gynecology And Perinatology Named After Academician V.I.KulakovВ» Ministry of Healthcare of the Russian Federation, Moscow, Russia, i_fedorov@oparina4.ru
⁵FSBI В«National Medical Research Center For Obstetrics, Gynecology And Perinatology Named After Academician V.I.KulakovВ» Ministry of Healthcare of the Russian Federation, Moscow, Russia, vvchagovets@gmail.com
⁶FSBI В«National Medical Research Center For Obstetrics, Gynecology And Perinatology Named After Academician V.I.KulakovВ» Ministry of Healthcare of the Russian Federation, Moscow, Russia, l_ezhova@oparina4.ru
⁷FSBI В«National Medical Research Center For Obstetrics, Gynecology And Perinatology Named After Academician V.I.KulakovВ» Ministry of Healthcare of the Russian Federation, Moscow, Russia, r_shmakov@oparina4.ru
⁸FSBI В«National Medical Research Center For Obstetrics, Gynecology And Perinatology Named After Academician V.I.KulakovВ» Ministry of Healthcare of the Russian Federation, Moscow, Russia, g_sukhikh@oparina4.ru

It is well-known that abnormal placental invasion is a condition characterized by pathological invasion of chorionic villi into the the basal layer of the uterus that is complicated by massive obstetric hemorrhage, blood transfusions, a need for hysterectomy and even mortality. The altered miRNA expression profiles were found by deep sequencing not only directly in the area of pathological invasion, but also in the outside distant placenta areas with more pronounced changes in the former case. An increase in the level of miR-21-5p, miR-25-3p, miR-92a-3p, miR-320a in maternal plasma may indicate abnormally invasiveВ placenta and potentially be used in the early diagnosis and management of this condition.