Poster (download)
513
Elena Voropaeva1, Yuriy Orlov2, Olga Beresina3, Tatyana Pospelova4, Viktoria Karpova5, Vladimir Maximov6, Elizaveta Melnikova7, Anastasia Ivanova8, Anna Gurageva9, Maria Churkina10
1IITPM – Branch of ICG SB RAS, vena.81@mail.ru
2I.M.Sechenov First Moscow State Medical University, orlov_yury@yahoo.com
3NSMU,, ovb-mail@ya.ru
4NSMU, postatgem@mail.ru
5State Regional Clinical Hospital, vicka-34@ngs.ru
6IITPM – Branch of ICG SB RAS, medik11@mail.ru
7IITPM – Branch of ICG SB RAS, jarinaleksi@list.ru
8IITPM – Branch of ICG SB RAS, ivanova_a_a@mail.ru
9IITPM – Branch of ICG SB RAS, annapalna1@mail.ru
10NSMU, nats.sagan@yandex.ru
In this study, based on the information presented in the specialized resource CBioPortal for Cancer Genomics database, the data on the diffuse large B-cell lymphoma (DLBCL) mutation profile detected by next generation sequencing (NGS) methods have been analyzed. The features associated with a high risk of secondary central nervous system (CNS) involvement have been highlighted. In patients with DLBCL and secondary CNS involvement, the most frequently mutated genes were MYD88, PIM1, CARD11 and CD79B. These genes related to the BCR/NF-kB signaling pathway. The MYD88, PIM1 and CD79B genes mutations were often combined and, in total, occurred in 39.6% of cases in patients with CNS relapsed DLBCL.
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