The cross-talk molecular pathways of glutamate and leptin receptors

Poster (download)

273

Anna L. Proskura¹, Mariya Yu. Islamova², Svetlana O. Vechkapova^3
1The Institute of Computational Technologies of SB RAS, annleop@mail.ru
²The Institute of Computational Technologies of SB RAS, m.yu.islamova@gmail.com
³The Institute of Computational Technologies of SB RAS, svetavech@yandex.ru

The adipocyte-derived hormone leptin is an important regulator of body weight and metabolism through activation of brain leptin receptors expressed in different brain regions such as the hypothalamus. Moreover, it has pro-cognitive and anti-depressive effects in the central nervous system. Leptin receptor expressed in the different brain areas particularly hippocampus where are they had a modulating effect on the synaptic plasticity regulation, synaptogenesis and promotes hippocampal-dependent learning and memory. Leptin directly influences on the glutamate receptors recycling in the hippocampal CA1 field through PI3K-signalling pathway. To dissect the mechanisms by which leptin induced of synaptic PIP3 generation we analyzed proteins domains structure which to involve in the counter-regulation hippocampal excitatory synaptic network.