Differentially expressed genes associated with TMPRSS2-ERG molecular subtype of prostate cancer

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Anastasiya Andreevna Kobelyatskaya¹, Elena Anatolevna Pudova², George Sergeevich Krasnov³, Anna Victorovna Kudryavtseva⁴, Kirill Mikhailovich Nyushko⁵, Boris Yakovlevich Alekseev^6
1EIMB RAS, kaa.chel@mail.ru
²EIMB RAS, pudova_elena@inbox.ru
³EIMB RAS, gskrasnov@mail.ru
⁴EIMB RAS, rhizamoeba@mail.ru
⁵FSBI NMRRC, kirandja@yandex.ru
⁶FSBI NMRRC, mnioi@mail.ru

Prostate cancer (PC) is one of the most common and socially significant oncological diseases in men. This study examined the transcriptome profile of the most common molecular genetic subtype of prostate cancer, TMPRSS2-ERG. As a result of bioinformatics analysis conducted on the basis of The Cancer Genome Atlas project data, 115 differentially expressed genes were identified for this study group, and in particular, the most over-expressing genes were identified: ALOX15, CACNA1D, EML6, HLA-DMB, NKAIN1, OGDHL, PLA1A, SYT13. Enrichment pathways analysis showed that these genes are participants in important oncologically significant pathways, which emphasizes the association of this molecular subtype with an unfavorable prognosis for prostate cancer.