Quantitative differences in the proteomic composition of the blood serum of patients with simple and paranoid schizophrenia

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Smirnova Liudmila, Laboratory of Molecular Genetics and Biochemistry, Mental Health Research Institute of Tomsk National Research Medical Center, Tomsk, Russia, lpsmirnova@yandex.ru
Semke Arkadiy, the Department of Endogenous Disorders Mental Health Research Institute of Tomsk National Research Medical Center. Tomsk, Russia, arkan1959@mail.ru
Zgoda Victor, Laboratory of systems biology, Institute of Biomedical Chemistry, Moscow, Russia, vic@ibmh.msk.su
Ivanova Svetlsna, Laboratory of Molecular Genetics and Biochemistry, Mental Health Research Institute of Tomsk National Research Medical Center, Tomsk, Russia, ivanovaniipz@gmail.com
Dmitrieva Elena, Laboratory of Molecular Genetics and Biochemistry, Mental Health Research Institute of Tomsk National Research Medical Center, Tomsk, Russia, lena-312tom@yandex.ru

The work analyzed the protein spectrum of blood serum of simple and paranoid schizophrenia. A set of proteins in schizophrenia was mainly associated with responsible for protein synthesis and the processes of transduction and translation; immune response, oxidative stress and apotosis, cell compataminization and cell contacts. In the blood serum of patients in the general group of schizophrenia, a significant increase in the number of RIPK1, mGluR6 receptors was revealed in comparison with healthy people. In addition, the amount of mGluR6 was significantly higher in patients with a simple form of schizophrenia than in patients with a paranoid form (p = 0.021). A quantitative assessment of the specific minor proteins that we studied using labeled standard peptides showed an increase in their number depending on the severity of the disease (a simple form of schizophrenia, leading negative symptoms)