Poster (download) Anastasiya A. Kotlyarova1, Konstantin Yu. Ponomarev2, Ekaterina A. Morozova3, Dina V. Korchagina4, Evgeniy V. Suslov5, Alla V. Pavlova6, Tatyana G. Tolstikova7, Konstantin P. Volcho8, Nariman F. Salakhutdinov91Research Institute of Clinical and Experimental Lymphology – a branch of the Institute of Cytology and Genetics of Siberian Branch of Russian Academy of Sciences, kotlyarova.anastasiya@yandex.ru2Novosibirsk Institute of Organic Chemistry of Siberian Branch of Russian Academy of Sciences, ponomarev@nioch.nsc.ru3Novosibirsk Institute of Organic Chemistry of Siberian Branch of Russian Academy of Sciences, ekaterina.morozoff@gmail.com4Novosibirsk Institute of Organic Chemistry of Siberian Branch of Russian Academy of Sciences, korchaga@nioch.nsc.ru5Novosibirsk Institute of Organic Chemistry of Siberian Branch of Russian Academy of Sciences, suslov@nioch.nsc.ru6Novosibirsk Institute of Organic Chemistry of Siberian Branch of Russian Academy of Sciences, alla.sudos@gmail.com7Novosibirsk Institute of Organic Chemistry of Siberian Branch of Russian Academy of Sciences, tg_tolstikova@mail.ru8Novosibirsk Institute of Organic Chemistry of Siberian Branch of Russian Academy of Sciences, volcho@nioch.nsc.ru9Novosibirsk Institute of Organic Chemistry of Siberian Branch of Russian Academy of Sciences, anvar@nioch.nsc.ru Currently, increasing physical performance is an urgent task, not only in the field of extreme conditions, for the purposes of sports and military medicine, but also in the pharmacology of a healthy person. The aim of this work is to study the effect of monoterpenoid derivatives with 3,7-diazabicyclo [3.3.1] nonane (bispidine) on the physical performance of mice. Physical endurance was studied in two tests: Porsolt forced swimming test with a load of 7% of body weight and running on a treadmill. To assess the effect of the investigated agents on locomotor activity, an open field test was performed. As a result, it was found that of the two compounds with the codes K1-456 and K1-458, the most effective increase in running and swimming duration is compound K1-458, containing residues of (-) – myrtenal linked to the bispidine moiety through the amino group, at a dose of 100 mg/kg after a single intragastric administration. It was also found that the studied agents statistically significantly increase locomotor activity, distance traveled, speed and reduce the time of the stationary moment when testing in the \”open field\”. Thus, derivatives of bispidine containing monoterpenoid residues are a promising new class of organic compounds for the search for new drugs to increase health.

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