Poster (download) Anastasia S. Shulyupova1, Arina A. Smelova2, Vasiliy V. Reshetnikov3, Natalya P. Bondar41Laboratory of Gene Expression Regulation Institute of Cytology and Genetics of Siberian Branch of the Russian Academy of Sciences, IРЎ&G SB RAS, shulyupova@bionet.nsc.ru2Epigenetics laboratory National Research Novosibirsk State University, NSU, smelovarina@gmail.com3Laboratory of Gene Expression Regulation Institute of Cytology and Genetics of Siberian Branch of the Russian Academy of Sciences, IРЎ&G SB RAS, vasiliyreshetnikov@bionet.nsc.ru4Laboratory of Gene Expression Regulation Institute of Cytology and Genetics of Siberian Branch of the Russian Academy of Sciences, IРЎ&G SB RAS, nbondar@bionet.nsc.ru The early postnatal period is critical for the development of the central nervous system and can predetermine subsequent behavioral patterns, so stress at this age can lead to long-term consequences in adulthood. In our work, we investigated effects early life stress on myelination. We assessed the expression of the genes associated with the myelin sneath (myelin basic protein – Mbp, myelin-associated oligodendrocyte basic protein – Mobp, proteolipid protein 1 – Plp1, proteolipid in compact myelin – Mal, myelin oligodendrocyte glycoprotein – Mog, choline-specific glycerophosphodiester-phosphodiesterase – Enpp6, UDP-glucuronosyltransferase – Ugt8a) in frontal cortex of mice. The greatest difference in the level of expression was found between groups with a maternal deprivation and a maternal separation from mothers: significant changes were shown for the Enpp6, Mal, Ugt8a genes and one of the Mobp gene transcripts. This may indicate a different extent of exposure to stressors. We can conclude that the stress in the early postnatal period affects the myelination process and can lead to impaired transmission of nerve impulses.

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