The impact of early-life stress on the expression of genes associated with the formation of the myelin sheath of neurons in the prefrontal cortex of 15-day-old male mice

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Anastasia S. Shulyupova¹, Arina A. Smelova², Vasiliy V. Reshetnikov³, Natalya P. Bondar^4
1Laboratory of Gene Expression Regulation Institute of Cytology and Genetics of Siberian Branch of the Russian Academy of Sciences, IРЎ&G SB RAS, shulyupova@bionet.nsc.ru
²Epigenetics laboratory National Research Novosibirsk State University, NSU, smelovarina@gmail.com
³Laboratory of Gene Expression Regulation Institute of Cytology and Genetics of Siberian Branch of the Russian Academy of Sciences, IРЎ&G SB RAS, vasiliyreshetnikov@bionet.nsc.ru
⁴Laboratory of Gene Expression Regulation Institute of Cytology and Genetics of Siberian Branch of the Russian Academy of Sciences, IРЎ&G SB RAS, nbondar@bionet.nsc.ru

The early postnatal period is critical for the development of the central nervous system and can predetermine subsequent behavioral patterns, so stress at this age can lead to long-term consequences in adulthood. In our work, we investigated effects early life stress on myelination. We assessed the expression of the genes associated with the myelin sneath (myelin basic protein – Mbp, myelin-associated oligodendrocyte basic protein – Mobp, proteolipid protein 1 – Plp1, proteolipid in compact myelin – Mal, myelin oligodendrocyte glycoprotein – Mog, choline-specific glycerophosphodiester-phosphodiesterase – Enpp6, UDP-glucuronosyltransferase – Ugt8a) in frontal cortex of mice. The greatest difference in the level of expression was found between groups with a maternal deprivation and a maternal separation from mothers: significant changes were shown for the Enpp6, Mal, Ugt8a genes and one of the Mobp gene transcripts. This may indicate a different extent of exposure to stressors. We can conclude that the stress in the early postnatal period affects the myelination process and can lead to impaired transmission of nerve impulses.