DNA damage to nervous tissue due to lead intoxication combined with glucose loading

Poster (download) Yakimova Natalya Leonidovna1, Andreeva Elizaveta Sergeevna2, Buinova Ekaterina Vladimirovna31Estern-Siberian Institute of Medical and Ecological Research, Angarsk, Russia, ynl-77@list.ru2Estern-Siberian Institute of Medical and Ecological Research, Angarsk, Russia, liza.2995@mail.ru3Estern-Siberian Institute of Medical and Ecological Research, Angarsk, Russia, byuncat@mail.ru The influence of heavy metals on various organs and systems is known. Diabetes disorders are also well understood. The component contribution of glucose loading was manifested in an increase in genotoxic lesions of nerve cells caused by lead intoxication. DNA damage in the tail of nerve cell comets after exposure to lead and glucose loading increased to 52.86 (13.16–73.34) percent compared to 25.28 (12.24–54.79) percent of people poisoned by lead. In animals exposed to lead and glucose, brain cells with high DNA damage in the tail of comets dominated the brain, 62.77 (54.68-70.87) percent of the cells were apoptosis-positive compared to 48.42 (38, 37-58.47) percent rats treated with lead acetate without glucose load.

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