Poster (download) Video (download) Daria Parshukova1, Liudmila Smirnova2, Ekaterina Dmitrieva3, Arkady Semke4, Vasily Yarnykh5, Svetlana Ivanova61Mental Health Research Institute Tomsk National Research Medical Center RAS, Susl2008@yandex.ru2Mental Health Research Institute Tomsk National Research Medical Center RAS, Lpsmirnova@yandex.ru3Mental Health Research Institute Tomsk National Research Medical Center RAS, Egdtomsk@mail.ru4Mental Health Research Institute Tomsk National Research Medical Center RAS, Asemke@mail.ru5University of Washington, Department of Radiology, yarnykh@uw.edu6Mental Health Research Institute Tomsk National Research Medical Center RAS, Ivanovaniipz@gmail.com It is well-known that the pathology of myelin and oligodendrocytes is involved in the pathogenesis of schizophrenia. Anomalies in oligodendrocytes and myelin can be a source of neuronal disruption. The discovery of catalytic antibodies (abzymes) allows us to investigate their pathological role in various conditions. One of the possible ways of inducing proteolytic antibodies is the appearance in the peripheral blood of a substrate in the form of damaged protein fragments. In our previous study, it was shown that the IgG of schizophrenia patients can hydrolyze the myelin basic protein – one of the main components of the central nervous system myelin.В  The study of IgG proteases in accessible biomaterial (serum) and their association with myelination disturbance in schizophrenia may be potential criteria for monitoring the severity of mental disorders.

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