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Daria Parshukova1, Liudmila Smirnova2, Ekaterina Dmitrieva3, Arkady Semke4, Vasily Yarnykh5, Svetlana Ivanova6
1Mental Health Research Institute Tomsk National Research Medical Center RAS, Susl2008@yandex.ru
2Mental Health Research Institute Tomsk National Research Medical Center RAS, Lpsmirnova@yandex.ru
3Mental Health Research Institute Tomsk National Research Medical Center RAS, Egdtomsk@mail.ru
4Mental Health Research Institute Tomsk National Research Medical Center RAS, Asemke@mail.ru
5University of Washington, Department of Radiology, yarnykh@uw.edu
6Mental Health Research Institute Tomsk National Research Medical Center RAS, Ivanovaniipz@gmail.com
It is well-known that the pathology of myelin and oligodendrocytes is involved in the pathogenesis of schizophrenia. Anomalies in oligodendrocytes and myelin can be a source of neuronal disruption. The discovery of catalytic antibodies (abzymes) allows us to investigate their pathological role in various conditions. One of the possible ways of inducing proteolytic antibodies is the appearance in the peripheral blood of a substrate in the form of damaged protein fragments. In our previous study, it was shown that the IgG of schizophrenia patients can hydrolyze the myelin basic protein – one of the main components of the central nervous system myelin.В The study of IgG proteases in accessible biomaterial (serum) and their association with myelination disturbance in schizophrenia may be potential criteria for monitoring the severity of mental disorders.
Thank you for exellent presentation. What is the advantage of the method you used (to determine the level of proteolytic activity of IgG) over the mapping of macromolecular proton fractions (faster, cheaper, more accurately, etc.)? How close is the prospect of its clinical use?