Oxana Zaparina1, Anna Kovner2, Maria Pakharukova3, Viacheslav Mordvinov41ICG SB RAS, zp.oksana.93@gmail.com2ICG SB RAS, kovner@bionet.nsc.ru3ICG SB RAS, NSU, pakharukova@bionet.nsc.ru4ICG SB RAS, mordvin@bionet.nsc.ru Opisthorchiasis caused by the liver fluke Opisthorchis felineus in the hepatobiliary system of humans and fish-eating mammals is widespread on Russian territory. Pathogenesis of opisthorchiasis is accompanied by structural and functional disorders of the liver, including the formation of foci of chronic inflammation, cholestasis, cholecystitis and precancerous changes in the epithelium of the bile ducts. In the result of study, we showed time- dependent oxidative lesions accumulation and hepatoprotective effect of various antioxidants  

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