Accumulation of oxidative hepatobiliary lesions during experimental opisthorchiasis

Oxana Zaparina¹, Anna Kovner², Maria Pakharukova³, Viacheslav Mordvinov^4
1ICG SB RAS, zp.oksana.93@gmail.com
²ICG SB RAS, kovner@bionet.nsc.ru
³ICG SB RAS, NSU, pakharukova@bionet.nsc.ru
⁴ICG SB RAS, mordvin@bionet.nsc.ru

Opisthorchiasis caused by the liver fluke Opisthorchis felineus in the hepatobiliary system of humans and fish-eating mammals is widespread on Russian territory. Pathogenesis of opisthorchiasis is accompanied by structural and functional disorders of the liver, including the formation of foci of chronic inflammation, cholestasis, cholecystitis and precancerous changes in the epithelium of the bile ducts.

In the result of study, we showed time- dependent oxidative lesions accumulation and hepatoprotective effect of various antioxidants