РЎognitive functions and polymorphism of the BDNF gene in patients with schizophrenia and healthy individuals

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Anastasiia Boiko¹, Ekaterina Mikhalitskaya², Elena Kornetova³, Svetlana Ivanova^4
1Mental Health Research Institute Tomsk NRMC, anastasya-iv@yandex.ru
²Mental Health Research Institute Tomsk NRMC, uzen63@mail.ru
³Mental Health Research Institute Tomsk NRMC, kornetova@sibmail.com
⁴Mental Health Research Institute Tomsk NRMC, ivanovaniipz@gmail.com

In a number of schizophrenia concepts, the neurocognitive deficiency is distinguished to a separate domain along with positive and negative disorders and it is an important predictor of the unfavorable prognosis of the course of the disease and the development of persistent social dysfunction. The contribution of genetic mechanisms has been proven in the variability of attention instability and long-term memory impairment. Brain derived neurotrophic factor (BDNF) plays an important role in cell differentiation, survival, long-term potentiation, synaptic plasticity, learning and memory. The aim of the research is to study cognitive functions in patients with schizophrenia and healthy persons, and identify associations between cognitive function and polymorphism of BDNF gene. It was a complex clinical and biological examination of 550 patients with schizophrenia and 485 healthy persons. Significant differences in the distribution of genotypes of polymorphism rs6265 in patients with schizophrenia and healthy individuals were not found. Assessment of cognitive functions was carried out in 160 patients with schizophrenia and 106 healthy individuals using the BACS scale. The data obtained indicate that according to all BACS tests, the indicators of cognitive function in patients with schizophrenia are significantly worse than in healthy controls. Associations of genotypes of polymorphism rs6265 of the BDNF gene were detected by performing subtests of the BACS scale.