Differentially methylation of ANKRD53 and GATA3 genes in human miscarriages with trisomy 16

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E. N. Tolmacheva¹, S.A.Vasilyev², O.Yu. Vasilyeva³, T.V. Nikitina⁴, E.A.Sazhenova⁵, A.V.Markov⁶, E.S. Serdyukova⁷, D.I. Zhigalina⁸, I.N.Lebedev^9
1Research Institute of Medical Genetics, Tomsk National Research Medical Center, Tomsk, katetolmacheva35@gmail.com
²Research Institute of Medical Genetics, Tomsk National Research Medical Center, Tomsk, stas.vasilyev@gmail.com
³Research Institute of Medical Genetics, Tomsk National Research Medical Center, Tomsk, vasilyeva.o.yu@gmail.com
⁴Research Institute of Medical Genetics, Tomsk National Research Medical Center, Tomsk, t.nikitina@medgenetics.ru
⁵Research Institute of Medical Genetics, Tomsk National Research Medical Center, Tomsk, elena.sazhenova@mail.ru
⁶Research Institute of Medical Genetics, Tomsk National Research Medical Center, Tomsk, anton.markov@medgenetics.ru
⁷National Research Tomsk State University, Tomsk, katya.serdyukova.1997@mail.ru
⁸Research Institute of Medical Genetics, Tomsk National Research Medical Center, Tomsk, dasha_150291@mail.ru
⁹Research Institute of Medical Genetics, Tomsk National Research Medical Center, Tomsk, igor.lebedev@medgenetics.ru

An excess dosage of the genes at the whole chromosome can lead to a disturbance of the epigenetic background of the entire genome. We analyzed the DNA methylation of several genes that are important for normal embryogenesis in miscarriages with aneuploidy and normal karyotype.