Differentially methylation of ANKRD53 and GATA3 genes in human miscarriages with trisomy 16

Poster (download) E. N. Tolmacheva1, S.A.Vasilyev2, O.Yu. Vasilyeva3, T.V. Nikitina4, E.A.Sazhenova5, A.V.Markov6, E.S. Serdyukova7, D.I. Zhigalina8, I.N.Lebedev91Research Institute of Medical Genetics, Tomsk National Research Medical Center, Tomsk, katetolmacheva35@gmail.com2Research Institute of Medical Genetics, Tomsk National Research Medical Center, Tomsk, stas.vasilyev@gmail.com3Research Institute of Medical Genetics, Tomsk National Research Medical Center, Tomsk, vasilyeva.o.yu@gmail.com4Research Institute of Medical Genetics, Tomsk National Research Medical Center, Tomsk, t.nikitina@medgenetics.ru5Research Institute of Medical Genetics, Tomsk National Research Medical Center, Tomsk, elena.sazhenova@mail.ru6Research Institute of Medical Genetics, Tomsk National Research Medical Center, Tomsk, anton.markov@medgenetics.ru7National Research Tomsk State University, Tomsk, katya.serdyukova.1997@mail.ru8Research Institute of Medical Genetics, Tomsk National Research Medical Center, Tomsk, dasha_150291@mail.ru9Research Institute of Medical Genetics, Tomsk National Research Medical Center, Tomsk, igor.lebedev@medgenetics.ru An excess dosage of the genes at the whole chromosome can lead to a disturbance of the epigenetic background of the entire genome. We analyzed the DNA methylation of several genes that are important for normal embryogenesis in miscarriages with aneuploidy and normal karyotype.    

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