Functional Roles of the E3 Ubiquitin Ligase HYD in Drosophila Tissues

Poster (download)

215

Iuliia Galimova1, Natalia Vladimirovna Dorogova2, Svetlana Fedorova3
1IMCB SB RAS, Novosibirsk, Russia, galimova@mcb.nsc.ru
2ICG SB RAS, Novosibirsk, Russia, dorogova@bionet.nsc.ru
3ICG SB RAS, Novosibirsk, Russia, fsveta@bionet.nsc.ru

Drosophila tumor suppressor HYD is required for the regulation of cell proliferation, growth and differentiation. HYD is involved in cell processes at different levels: it can regulate gene expression by binding to its promoters, it binds to some RNA for gene silencing and it participates in protein degradation due to its ubiquitin-ligase activity. Analysis of Drosophila hyd mutants revealed that HYD functions depend on tissue and stage of development: misexpression in larval somatic tissues causes over-proliferation, defects of meiosis and spermatid differentiation in spermatogenesis, and massive cell death with occasional germline overproliferation during oogenesis.

0 0 vote
Article Rating
Subscribe
Notify of
guest
7 Comments
Inline Feedbacks
View all comments
relaxing instrumental music

relaxing instrumental music

bossa nova piano
5 months ago

bossa nova piano

relax
5 months ago

relax

relaxing piano music
5 months ago

relaxing piano music

relax everyday
5 months ago

relax everyday

healing music
3 months ago

healing music

relaxing cafe ambience

relaxing cafe ambience