Functioning of unique nitrile-detoxifying system in soil xenobiotic degrader Rhodococcus rhodochrous: a whole-genome transcriptomic approach

Konstantin V Lavrov¹, Andrey D Novikov², Tatyana I Kalinina³, Artem S Kasianov⁴, Alexander S Yanenko^5
1NRC “Kurchatov institute – GosNIIgenetika”, lavrov.ko@gmail.com
²NRC “Kurchatov institute – GosNIIgenetika”, alexm19@mail.ru
³NRC “Kurchatov institute – GosNIIgenetika”, tatyana.i.kalinina@googlemail.com
⁴Vavilov Institute of General Genetics, artem.kasianov@gmail.com
⁵NRC “Kurchatov institute – GosNIIgenetika”, yanenko@genetika.ru

Organic nitriles are significant participants of interactions between soil living organisms, thus their synthesis and degradation are of interest. Using transcriptomic approach, we revealed a genetic cascade, realizing nitrile degradation in powerful nitrile degrader – Rhodococcus rhodochrous. We also hypothesized a genetic “network” for nitrile/amide utilization, connected with cobalt homeostasis.