Genetic mapping of QTLs controlling the ISIAH hypertensive rat behavior in an open field tests

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Olga Redina¹, Svetlana Smolenskaya², Arcady Markel^3
1Laboratory. of Evolutional Genetics, Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk, Russia, oredina@bionet.nsc.ru
²Laboratory of Evolutional Genetics, Wheat Genetics Laboratory, Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk, Russia, svsmol@ngs.ru
³Laboratory. of Evolutional Genetics, Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk, Russia, markel@bionet.nsc.ru

Genetic mapping of QTLs controlling the ISIAH hypertensive rat behavior in an open field tests evaluating research behavior, the level of anxiety and motor activity of animals was performed. The work was carried out using two groups of male hybrid rats F₂(ISIAHxWAG) of different ages – 3-4 months (n = 103) and 6 months (n = 126) obtained by crossing hypertensive ISIAH and normotensive WAG rats whose behaviors are significantly different in all six tests in an open field taken in the analysis: the latency, the motor activity at 1-st minute of the test, motor activity on the periphery, grooming on the periphery, rearing on the periphery, defecation score. In both groups of rats, genetic loci associated with the studied traits of behavior were found and the common loci associated with both the behavioral traits and traits related to the hypertension development were identified. The results of our work suggest that genes that control behavioral patterns of ISIAH rats can either be closely linked to genes involved in the control of traits associated with the hypertensive status of these rats, or, in some loci, may have a pleiotropic effect on both behavioral traits and on the traits associated with the hypertensive status of ISIAH rats.