Loci and genes involved in chronic musculoskeletal pain identified via analysis of genetically independent pain phenotypes

Yakov Tsepilov¹, Maxim B. Freidin², Alexandra S. Shadrina³, Sodbo Z. Sharapov⁴, Elizaveta E. Elgaeva⁵, Jan van Zundert⁶, Lennart РЎ. Karssen⁷, Pradeep Suri⁸, Frances M.K. Williams⁹, Yurii S. Aulchenko^10
1Novosibirsk State University, drosophila.simulans@gmail.com
²King’s College London, maxim.freydin@kcl.ac.uk
³Novosibirsk State University, weiner.alexserg@gmail.com
⁴Novosibirsk State University, sharapovsodbo@gmail.com
⁵Novosibirsk State University, elizabeth.elgaeva@gmail.com
⁶Maastricht University Medical Centre, jan.vanzundert@zol.be
⁷PolyOmica, l.c.karssen@polyomica.com
⁸VA Puget Sound Health Care System, pradeepsuri1@gmail.com
⁹King’s College London, frances.williams@kcl.ac.uk
¹⁰Novosibirsk State University, y.s.aulchenko@polyomica.com

We have evaluated four genetically independent pain phenotypes of four common chronic musculoskeletal pains (GIPs). We assume that the first GIP represents a biopsychological component of chronic musculoskeletal pain, related to physiological and psychological aspects and possibly reflecting pain perception and processing.