Opportunities of Trabecular Bone Score to Evaluate Ankylosing Spondilitis Structural Progression in Young Male Patients

Kolpakov Konstantin¹, Korolev Maxim², Letyagina Elena³
¹Laboratory of Connective Tissue Disease, RICEL – Branch of ICG SB RAS Novosibirsk, Russian Federation, elmad95@mail.ru
²Laboratory of Connective Tissue Disease, RICEL – Branch of ICG SB RAS Novosibirsk, Russian Federation, kormax@bk.ru
³Laboratory of Connective Tissue Disease, RICEL – Branch of ICG SB RAS Novosibirsk, Russian Federation, elena_letyagina@list.ru

Ankylosing spondylitis (AS) is a chronic progressive systemic inflammatory disease, with a primary lesion of the spine and sacroiliac joints characterized by simultaneously running processes of osteogenesis (syndesmophytes) and osteoresorption (osteoporosis). The aim of this work is to investigate trabecular bone score (TBS) correlation with signs of structural progression of AS in the males before 50. Fourteen AS male patients before 50 without osteoporosis are included in investigation. The relationships between TBS, the Kellgren sacroiliitis stage, and BMD indices in different parts of the skeleton were studied using Spearman correlation analysis. A strong negative correlation was found between TBS and the X-ray stage of Kellgren sacroiliitis (r = -0.69; p <0.05) in men before 50 with AS. BMD does not reflect the degree of structural disturbances and the risks of spinal fractures in men before 50 with AS in the absence of other causes of secondary osteoporosis.

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Vadim Nimaev

3 years ago

Thank you for your presentation. Small remark. There are 5 levels of BMD in different places (Table “Patient’s chracteristic”) without exact indication of place (lumbar spine, femur etc).

Olga Fazullina

Very interesting data received by you. I have two questions. There is no BMI in the patient profile. Were there obese men in this group? The value of TBS in postmenopausal women> 1.35 is normal. Is there any data in the literature about normal values in men?