Poster (download) Kolpakov Konstantin1, Korolev Maxim2, Letyagina Elena31Laboratory of Connective Tissue Disease, RICEL – Branch of ICG SB RAS Novosibirsk, Russian Federation, elmad95@mail.ru2Laboratory of Connective Tissue Disease, RICEL – Branch of ICG SB RAS Novosibirsk, Russian Federation, kormax@bk.ru3Laboratory of Connective Tissue Disease, RICEL – Branch of ICG SB RAS Novosibirsk, Russian Federation, elena_letyagina@list.ru Ankylosing spondylitis (AS) is a chronic progressive systemic inflammatory disease, with a primary lesion of the spine and sacroiliac joints characterized by simultaneously running processes of osteogenesis (syndesmophytes) and osteoresorption (osteoporosis). The aim of this work is to investigate trabecular bone score (TBS) correlation with signs of structural progression of AS in the males before 50. Fourteen AS male patients before 50 without osteoporosis are included in investigation. The relationships between TBS, the Kellgren sacroiliitis stage, and BMD indices in different parts of the skeleton were studied using Spearman correlation analysis. A strong negative correlation was found between TBS and the X-ray stage of Kellgren sacroiliitis (r = -0.69; p <0.05) in men before 50 with AS. BMD does not reflect the degree of structural disturbances and the risks of spinal fractures in men before 50 with AS in the absence of other causes of secondary osteoporosis.

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