Relationship Cytokines Lymphs and Mesenteric Lymph Nodes Rats at Chemotherapy Breast Cancer

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Kazakov Oleg1, Poveshchenko Alexander2, Orlov Nikolai3, Kabakov Alexey4, Lykov Alexander5, Strunkin Dmitry6, Konenkov Vladimir7
1Research Institute of Clinical and Experimental Lymphology – Branch of the Institute of Cytology and Genetics,Siberian Branch of the Russian Academy of Sciences, kazakoff_oleg@mail.ru
2Research Institute of Clinical and Experimental Lymphology – Branch of the Institute of Cytology and Genetics,Siberian Branch of the Russian Academy of Sciences, poveshchenkoa200@mail.ru
3Research Institute of Clinical and Experimental Lymphology – Branch of the Institute of Cytology and Genetics,Siberian Branch of the Russian Academy of Sciences, nbo@ngs.ru
4Research Institute of Clinical and Experimental Lymphology – Branch of the Institute of Cytology and Genetics,Siberian Branch of the Russian Academy of Sciences, kabakov_av85@mail.ru
5Research Institute of Clinical and Experimental Lymphology – Branch of the Institute of Cytology and Genetics,Siberian Branch of the Russian Academy of Sciences, aplykov2@mail.ru
6Research Institute of Clinical and Experimental Lymphology – Branch of the Institute of Cytology and Genetics,Siberian Branch of the Russian Academy of Sciences, Strunkind@mail.ru
7Research Institute of Clinical and Experimental Lymphology – Branch of the Institute of Cytology and Genetics,Siberian Branch of the Russian Academy of Sciences, vikonenkov@gmail.com

At correlating the morphometry of mesenteric lymph nodes and the concentration of cytokines in the lymph of the thoracic duct in breast cancer induced by intramammary administration of N-methyl-n-nitrosourea, chemotherapy according to the CMF scheme, compared with breast cancer without treatment, positive relationships were found that may indicate on increase in the immunomodulatory and antitumor action of cytokines. The correlation of interferon IFNОі with small lymphocytes (the number which increased) and macrophages in germinative centers and mitotic dividing cells in medullary substance, correlation in germinative centers of immunoblasts with MIP-1О± and increase of number small lymphocytes in the thymus dependent zone of lymph nodes, correlation in medullary substance of interleukin IL-17 with mature plasma cells (the number of which is increased), correlation of interleukin IL-18 with mature plasma cells in the medullary sinuses.

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