Search for single nucleotide polymorphisms (SNPs) associated with hypertension in the genome of senescence-accelerated OXYS rats

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Vasiliy A. Devyatkin¹, Natalia A. Muraleva², Olga E. Redina³, Nataliya Kolosova^4
1Institute of Cytology and Genetics SB RAS, devyatkin@bionet.nsc.ru
²Institute of Cytology and Genetics SB RAS, myraleva@bionet.nsc.ru
³Institute of Cytology and Genetics SB RAS, oredina@bionet.nsc.ru
⁴Institute of Cytology and Genetics SB RAS, Nnnnn80@ngs.ru

Aging is a risk factor for many diseases, but the likelihood of developing with age also depends on genetic factors, environmental conditions, lifestyle, and the presence of other pathologies. The OXYS rat strain (ICG SB RAS) is a unique model for studying the mechanisms of aging, as already at an early age these animals develop a whole complex of age-dependent diseases, including cataracts, retinopathy, osteoporosis, hypertension and Alzheimer’s-like pathology. Although hypertension has risk factors typical of age-related diseases, it itself is a risk factor for many other pathologies. However, the complex senile phenotype does not appear in other hypertensive models, even with higher blood pressure. The aim of this study was, based on the results of RNA-Seq, the search for single nucleotide polymorphisms that could contribute to the development of hypertension in OXYS rats with accelerated aging. We found that OXYS rats are genetically far from other strains and presumably have their own bases for the development of hypertension, which may determine the absence of the senile phenotype of OXYS rats in hypertensive rat strains.