Toxicity of Fucoxanthin on Balb/c Mice Splenocytes and Thymocytes

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Alexander Lykov¹, Lubov Rachkovskaya², Olga Poveshchenko³, Maria Surovtseva⁴, Irina Kim⁵, Edmund Rachkovsky⁶, Maxim Korolev⁷, Ruslan Gevorgiz⁸, Svetlana Zheleznova⁹, Anastasiya Kotlyarova¹⁰, Andrey Letyagin^11
1Research Institute of Clinical ans Experimental Lymphology- Branch of the Institute of Cytology and Genetics SB RAS, aplykov2@mail.ru
²Research Institute of Clinical ans Experimental Lymphology- Branch of the Institute of Cytology and Genetics SB RAS, lymphology@niikel.ru
³Research Institute of Clinical ans Experimental Lymphology- Branch of the Institute of Cytology and Genetics SB RAS, poveschenkoov@yandex.ru
⁴Research Institute of Clinical ans Experimental Lymphology- Branch of the Institute of Cytology and Genetics SB RAS, mfelde@ngs.ru
⁵Research Institute of Clinical ans Experimental Lymphology- Branch of the Institute of Cytology and Genetics SB RAS, kii5@yandex.ru
⁶Research Institute of Clinical ans Experimental Lymphology- Branch of the Institute of Cytology and Genetics SB RAS, lymphology@niikel.ru
⁷Research Institute of Clinical ans Experimental Lymphology- Branch of the Institute of Cytology and Genetics SB RAS, kormax@bk.ru
⁸A.O. Kovalevsky Institute of Biology of the Southern Seas RAS, r.gevorgiz@yandex.ru
⁹A.O. Kovalevsky Institute of Biology of the Southern Seas RAS, zheleznovasveta@yandex.ru
¹⁰Research Institute of Clinical ans Experimental Lymphology- Branch of the Institute of Cytology and Genetics SB RAS, kotlyarova.anastasiya@yandex.ru
¹¹Research Institute of Clinical ans Experimental Lymphology- Branch of the Institute of Cytology and Genetics SB RAS, letyaginay@bionet.nsc.ru

This work described toxicity of composition of fucoxanthin with particles of porous aluminum oxide with polydimethylsiloxane (Fx@Al/PDMS) in mice lymphocytes. Effects of Fx@Al/PDMS on Balb/c mice splenocytes and thymocytes viability, and proliferation, and intracellular myeloperoxidase activity, and nitric oxide (NO) production, and apoptosis were studied. It was shown that short-term (24 h) and long-term (129 h) incubation lymphocytes with Fx@Al/PDMS did not have any adverse effect on functional properties of splenocytes and thymocytes.