• June 29, 2020
  • N/A

Toxicity of Fucoxanthin on Balb/c Mice Splenocytes and Thymocytes

Poster (download) Alexander Lykov1, Lubov Rachkovskaya2, Olga Poveshchenko3, Maria Surovtseva4, Irina Kim5, Edmund Rachkovsky6, Maxim Korolev7, Ruslan Gevorgiz8, Svetlana Zheleznova9, Anastasiya Kotlyarova10, Andrey Letyagin111Research Institute of Clinical ans Experimental Lymphology- Branch of the Institute of Cytology and Genetics SB RAS, aplykov2@mail.ru2Research Institute of Clinical ans Experimental Lymphology- Branch of the Institute of Cytology and Genetics SB RAS, lymphology@niikel.ru3Research Institute of Clinical ans Experimental Lymphology- Branch of the Institute of Cytology and Genetics SB RAS, poveschenkoov@yandex.ru4Research Institute of Clinical ans Experimental Lymphology- Branch of the Institute of Cytology and Genetics SB RAS, mfelde@ngs.ru5Research Institute of Clinical ans Experimental Lymphology- Branch of the Institute of Cytology and Genetics SB RAS, kii5@yandex.ru6Research Institute of Clinical ans Experimental Lymphology- Branch of the Institute of Cytology and Genetics SB RAS, lymphology@niikel.ru7Research Institute of Clinical ans Experimental Lymphology- Branch of the Institute of Cytology and Genetics SB RAS, kormax@bk.ru8A.O. Kovalevsky Institute of Biology of the Southern Seas RAS, r.gevorgiz@yandex.ru9A.O. Kovalevsky Institute of Biology of the Southern Seas RAS, zheleznovasveta@yandex.ru10Research Institute of Clinical ans Experimental Lymphology- Branch of the Institute of Cytology and Genetics SB RAS, kotlyarova.anastasiya@yandex.ru11Research Institute of Clinical ans Experimental Lymphology- Branch of the Institute of Cytology and Genetics SB RAS, letyaginay@bionet.nsc.ru This work described toxicity of composition of fucoxanthin with particles of porous aluminum oxide with polydimethylsiloxane (Fx@Al/PDMS) in mice lymphocytes. Effects of Fx@Al/PDMS on Balb/c mice splenocytes and thymocytes viability, and proliferation, and intracellular myeloperoxidase activity, and nitric oxide (NO) production, and apoptosis were studied. It was shown that short-term (24 h) and long-term (129 h) incubation lymphocytes with Fx@Al/PDMS did not have any adverse effect on functional properties of splenocytes and thymocytes.

Read More

MICRORNAS (221, 429) ARE CORRELATION WITH LYMPHOCYTES OF AXILLARY LYMPH NODES IN EXPERIMENTAL BREAST CANCER

Poster (download) Aleksey Kabakov1, Alexandr Lykov2, Oleg Kazakov3, Alexandr Poveshchenko4, Olga Poveshchenko5, Dmitriy Strunkin6, Lyudmila Gulyaeva7, Andrey Letyagin8, Vladimir Konenkov91RICEL-Branch of IC&G SB RAS, kabakov_av@mail.ru2RICEL-Branch of IC&G SB RAS, aplykov2@mail.ru3RICEL-Branch of IC&G SB RAS, kazakoff_oleg@mail.ru4RICEL-Branch of IC&G SB RAS, poveshchenkoa200@mail.ru5RICEL-Branch of IC&G SB RAS, poveschenkoov@yandex.ru6RIMBB FRC FTM, strunkind@mail.ru7RIMBB FRC FTM, gulyaeva@soramn.ru8RICEL-Branch of IC&G SB RAS, letyaginay@bionet.nsc.ru9RICEL-Branch of IC&G SB RAS, vikonenkov@gmail.com The study of concentration miRNA (21, 221, 222, and 429) in serum, lymph of the thoracic duct and breast cancer tissue, as well as the cellular composition of axillary lymph node in Wistar female rats in chemically induced breast cancer. Concentration microRNA (-221, -429) in the tissues breast cancer and lymph are correlated with a decrease in number of lymphocytes in medullary cords of axillary lymph nodes.

Read More