Genetic aspects of internet-dependence in teenagers

Poster (download) Marina Smolnikova1, Sergey Tereshchenko21Scientific Research Institute of Medical Problems of the North FRC KSC SB RAS, smarinv@yandex.ru2Scientific Research Institute of Medical Problems of the North FRC KSC SB RAS, legise@mail.ru The rapid emergence and spread of Internet addiction in adolescent populations, combined with a rapid change in consumed content due to mobile access availability and the new access devices, are new challenges for classical psychology and fundamental medicine that require urgent solutions. The presence of the genetic component of Internet addiction was convincingly shown in different populations, but to date the specific genes involved in the mechanisms of such heritability have not been well identified. The aim of the study was to investigate the role of candidate neurotransmitters and to perform a population analysis of candidate genes polymorphisms for the Internet addiction formation. As a result of the analysis, 7 Internet-dependent adolescents and 39 adolescents with a tendency to Internet-dependent behavior were identified. The frequencies of genotype distribution in the population sampling of Caucasians (n = 302) В were obtained: * CC 59.6%, * CT 40.4%, * TT 0% (rs1800497 DRD2); * AA 23.8%, AG 52.4%, * GG 23.8% (rs4680 COMT); * CC 37.4%, * CG 46.0%, * GG 16.6% (rs2229910 NTRK3). The results will help to open new perspectives in assessing the fundamental neurobiological causes for the Internet addiction and the personalization of therapeutic approaches in Internet dependent adolescents.

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Dysbiosis in the Gut Microbiota of Adolescents with Obesity

Poster (download) Video (download) Novikova Evgenia Anatolyevna1, Bairova Tatyana Ananyevna2, Belkova Natalia Leonidovna3, Pogodina Anna Valeryevna4, Romanitsa Anastasia Igorevna5, Rychkova Lyubov Vladimirovna61Laboratory of Infectology and Immunoprophylaxis in Pediatrics Scientific РЎentre of Family Health and Human Reproduction Problems Irkutsk, Russia, europe411@mail.ru2Laboratory of Personalized Medicine Scientific РЎentre of Family Health and Human Reproduction Problems Irkutsk, Russia, tbairova38@mail.ru3Laboratory of Microbiome and Microecology Scientific РЎentre of Family Health and Human Reproduction Problems Irkutsk, Russia, nlbelkova@gmail.com4Laboratory of Pediatrics and Cardiovascular Pathology Scientific РЎentre of Family Health and Human Reproduction Problems Irkutsk, Russia, pogodina_av@inbox.ru5Laboratory of Pediatrics and Cardiovascular Pathology Scientific РЎentre of Family Health and Human Reproduction Problems Irkutsk, Russia, f1693@rambler.ru6Director and Head of Pediatry Department Scientific РЎentre of Family Health and Human Reproduction Problems Irkutsk, Russia, rychkova.nc@gmail.com Gut microbiota plays a fundamental role in the pathogenesis of metabolic disorders including obesity. Gut microbial dysbiosis induces immune and metabolic disturbances. We wanted to find out a gut microbiota composition at adolescents with obesity and normal weight. The examined group included 40 adolescents. There were 18 obese adolescents with SDS BMI=2.77В±0.55 (OB), and 22 adolescents with SDS BMI=0.01В±0.50 (CO). The metagenome sequencing of V3-V4 variable regions of 16S rDNA was done by Novogene Company (China). Data were analyzed using the StatSoft STATISTICA 6.0 software package. Statistical significance was accepted at the p<0.05 level. Microbial richness indices and biodiversity indices were similar in the groups with obesity and normal weight. No difference was found between two groups in the phyla Firmicutes, Bacteroidetes, Proteobacteria, Actinobacteria, and in the following genera Bacteroides, Alistipes, Subdoligranulum, Megasphaera, Blautia, Akkermansia, Odoribacter, Faecalibacterium, Lactobacillus, Bifidobacterium, and Streptococcus. As well as, P/A ratio along with B/F was comparable in both groups. Nevertheless, it should be noted that significant differences in the gut microbiota composition were found for phylotypes. The obese participants had a 2-fold decrease in Enterobacter (42 (13-61) in OB, 167 (42-371) in CO, p=0.02), and an increase – in the Anaerotruncus phylotype (326 (215-732) in OB, 226 (165-320) in CO, p=0.04). Summing up, results point to the dysbiosis of the gut microbiota in adolescences with obesity due to a prevalence of bacterial groups belonging to the phylotype Anaerotruncus (the phylum Firmicutes), whereas the Enterobacter phylotype (the phylum Proteobacteria) is underrepresented.

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