The effect of round-the-clock illumination on blood hemoglobin level, body composition and endurance of C57Bl/6 mice

Poster (download) Irina Yurievna Ishchenko1, Svetlana Viktorovna Michurina2, Andrey Yurievich Letyagin3, Maxim Aleksandrovich Korolev4, Lyubov Nikiforovna Rachkovskaya5, Anna Stanislavovna Khotskina6, Nikita Valeryevich Khotskin7, Svetlana Olegovna Maslennikova8, Evgenii L. Zavjalov91Group of experimental pharmacology SRICEL – a branch of ICG SB RAS Novosibirsk, Russia, irenisch@mail.ru2Group of experimental pharmacology SRICEL – a branch of ICG SB RAS Novosibirsk, Russia, s.michurina@ngs.ru3Laboratory of pharmaceutical technologies SRICEL – a branch of ICG SB RAS, letyagin-andrey@yandex.ru4Laboratory of connective tissue pathology SRICEL – a branch of ICG SB RAS Novosibirsk, Russia, kormax@bk.ru5Laboratory of pharmaceutical technologies SRICEL – a branch of ICG SB RAS Novosibirsk, Russia, noolit@niikel.ru6Center of genetic resources of laboratory animals ICG SB RAS Novosibirsk, Russia, dotcenko@bionet.nsc.ru7Sector of genetic collections of neuropathologies ICG SB RAS Novosibirsk, Russia, shverter@mail.ru8Center of genetic resources of laboratory animals ICG SB RAS Novosibirsk, Russia, maslennikova@bionet.nsc.ru9Center of genetis resources of laboratory animals ICG SB RAS Novosibirsk, Russia, zavjalov@bionet.nsc.ru Введите абстрактную аннотацию ТОЛЬКО здесь Эффекты круглосуточного освещения были изучены РЅР° самцах мышей C57Bl / 6. Масса тела мышей увеличилась после РґРІСѓС… недель 24-часового освещения (24 часа). Р РѕСЃС‚ массы тела был отмечен Р·Р° счет увеличения мышечной массы. Уровень гемоглобина РІ РєСЂРѕРІРё снизился РІ конце эксперимента. РњС‹ обнаружили снижение общего времени зависания РЅР° 14-Р№ день эксперимента.

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Continuous glucose monitoring parameters in insulin-treated type 2 diabetic patients: relationships with obesity and body composition

Poster (download) Julia F. Semenova1, Olga N. Fazullina21Laboratory of Endocrinology Research Institute of Clinical and Experimental Lymphology – Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences(RICEL – Branch of IC&G SB RAS) Novosibirsk, Russia, ekmxtyjr@yandex.ru2Laboratory of Endocrinology Research Institute of Clinical and Experimental Lymphology – Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (RICEL – Branch of IC&G SB RAS) Novosibirsk, Russia, fazullina@ngs.ru Background and aim: Obesity and associated insulin resistance can modify daily blood glucose fluctuations in patients with diabetes. The aim of our study was to determine the relationships between obesity, body composition and daily dynamics of glucose, assessed by continuous glucose monitoring (CGM), in patients with type 2 diabetes treated with insulin. Materials and Methods: One hundred and thirty six insulin-treated patients with type 2 diabetes were examined. Real-time or blinded CGM was performed using Medtronic CGM devices in hospital settings. Time in ranges and a panel of GV parameters were derived from CGM recordings. Results: Patients with obesity, as compared to those without, demonstrated significantly reduced Time Below Range (p<0.001), Low Blood Glucose Index (p<0.001), Lability Index (p=0.04), Men Absolute Glucose (p=0.03) and a tendency to lower Mean Amplidude of Glucose Excursions (p=0.08) and higher glycated hemoglobin HbA1c (p=0.07). There were negative correlations between total fat mass and Standard Deviation (r=-0.53, p=0.0008), Mean Amplitude of Glucose Excursions (r=-0.38, p=0.02), Lability Index (r=-0.51, p=0.0008), High Blood Glucose Index (r=-0.33, p=0.04) and MAG (r=-0.57, p=0.0001). Truncal fat mass, android and gynoid fat mass demonstrated negative correlations with these GV parameters also. Conclusions: These data demonstrate the association between obesity, body composition and CGM parameters in insulin-treated type 2 diabetic subjects. The presence of obesity and accumulation of adipose tissue is associated with reduced GV and diminished risk of hypoglycemia.

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Clinical and metabolic parameters associated with time in ranges and glucose variability in patients with type 2 diabetes treated with insulin

Poster (download) Julia F. Semenova1, Maksim V. Dashkin2, Olga N. Fazullina31Laboratory of Endocrinology Research Institute of Clinical and Experimental Lymphology – Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences(RICEL – Branch of IC&G SB RAS) Novosibirsk, Russia, ekmxtyjr@yandex.ru2Research Institute of Clinical and Experimental Lymphology – Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (RICEL – Branch of IC&G SB RAS) Novosibirsk, Russia, mdashkin@invitro.ru3Laboratory of Endocrinology Research Institute of Clinical and Experimental Lymphology – Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences(RICEL – Branch of IC&G SB RAS) Novosibirsk, Russia, fazullina@ngs.ru Background and aim: Continuous glucose monitoring (CGM) provides an excellent opportunity for in-depth assessment of glycemic control and glucose variability (GV) in diabetic subjects. The aim of our study was to determine the clinical and metabolic parameters associated with non-targeted time in range (TIR) increased GV in patients with type 2 diabetes (T2D) treated with insulin.В Materials and Methods: One hundred and thirty six insulin-treated patients with T2D were included. Real-time or blinded CGM was performed using Medtronic CGM devices. The TIR and Mean Amplitude of Glucose Excursion (MAGE) were estimated. The advance glycation end-products (AGEs) levels were measured in blood serum by ELISA.В Results: Patients with non-targeted TIR (>70%) had higher glycated hemoglobin HbA1c, triglycerides and proteinuria as compared to those with targeted TIR. Urinary albumin-to-creatinine ratio tended to be higher in patients with non-targeted TIR also. Patients with higher MAGE (>4.5 mmol/l) demonstrated lower levels of triglycerides and uric acid and increased AGEs levels as compared to those with MAGE <4.5 mmol/l.В Conclusions: In T2D subjects, non-targeted TIR is associated with hypertriglyceridemia and proteinuria, meantime, increased MAGE is related to lower serum levels of triglycerides and uric acid and higher levels of AGEs.  

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