Loci and genes involved in chronic musculoskeletal pain identified via analysis of genetically independent pain phenotypes

Yakov Tsepilov1, Maxim B. Freidin2, Alexandra S. Shadrina3, Sodbo Z. Sharapov4, Elizaveta E. Elgaeva5, Jan van Zundert6, Lennart С. Karssen7, Pradeep Suri8, Frances M.K. Williams9, Yurii S. Aulchenko101Novosibirsk State University, drosophila.simulans@gmail.com2King’s College London, maxim.freydin@kcl.ac.uk3Novosibirsk State University, weiner.alexserg@gmail.com4Novosibirsk State University, sharapovsodbo@gmail.com5Novosibirsk State University, elizabeth.elgaeva@gmail.com6Maastricht University Medical Centre, jan.vanzundert@zol.be7PolyOmica, l.c.karssen@polyomica.com8VA Puget Sound Health Care System, pradeepsuri1@gmail.com9King’s College London, frances.williams@kcl.ac.uk10Novosibirsk State University, y.s.aulchenko@polyomica.com We have evaluated four genetically independent pain phenotypes of four common chronic musculoskeletal pains (GIPs). We assume that the first GIP represents a biopsychological component of chronic musculoskeletal pain, related to physiological and psychological aspects and possibly reflecting pain perception and processing.

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